SugarBind Data Base
Following the publication of the article entitled : “SugarBind Database (SugarBindDB) : A resource of pathogen lectins and corresponding glycan targets” the release of the new version of the sugarbind database by the Swiss Institute of Bioinformatics has been announced on December 20th 2013. The data base is freely available at http://sugarbind.expasy.org/
SugarBindDB has been created from publicly-available information. First an on-line literature search locates candidate articles published in peer-reviewed scientific journals. Then abstracts are screened for relevance, and articles that appear likely to contain information on the binding of a human pathogen to a specific glycan are acquired, printed, and marked for data extraction. Reviews are used to identify primary literature, but are generally not cited in the database. Fewer than 5% of information sources include textbooks and conference proceedings.
Only sugar sequences that demonstrate consistent binding to pathogen lectins are entered into SugarBindDB. In some cases, authors have identified a precise lectin binding site or “glycotope” within a larger carbohydrate structure, while in others an entire oligosaccharide is listed.