Privateer : Software for the Conformational Validation of Carbohydrate Structures

Carbohydrates, including O- and N-glycans attached to protein and lipid structures, are increasingly being studied in cellular biology. Crystallographic refinement of sugars is, however, poorly performed, thus leading to thousands of incorrect structures having been deposited in the Protein Data Bank (PDB). Privateer is a new software package aimed at the detection and prevention of conformational, regiochemical and stereochemical anomalies in cyclic monosaccharide structures.

Privateer is distributed by CCP4 [(http://www.ccp4.ac.uk/html/privateer.html]

A graphical user interface, fully automating the validation, correction and rerefinement process, and providing access to interactive HTML5 and JavaScript graphical reports, will be available in the upcoming CCP4 7.0 release.