The use of multivalent carbohydrate compounds...

The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery of novel antiviral agents. One of the main problems with this approach, however, is that it is difficult to make compounds of an adequate size and multivalency to mimic natural systems such as viruses. As a result of an international collaborative endeavour, a water-soluble tridecafullerenes decorated with 120 peripheral carbohydrate subunits, has been syntyhesized. The synthesis proceeds in one step starting from hexakis adducts of [60]fullerene by using copper-catalysed azide–alkyne cycloaddition click chemistry.

Infection assays show that these superballs are potent inhibitors of cell infection by an artificial Ebola virus with half-maximum inhibitory concentrations in the subnanomolar range.