Transforming Glycoscience. A Road map for the Future
A recent report of the United States National Academy of Sciences entitled “Transforming Glycoscience. A Road map for the Future“ presents the current problems in Glycomics, Health/Disease, Energy and Materials and makes recommendations to achieve a more complete understanding of glycoscience and translate its impact on health, energy and material sciences. These can be summarized as follows :
- Development of transformative methods for the facile synthesis of carbohydrates and glycoconjugates.
- Development of transformative tools for detection, imaging, separation and high-resolution structure of carbohydrate structures and complex mixtures
- Development of transformative capabilities for perturbing carbohydrate and glycoconjugate structure, recognition, metabolism, and biosynthesis
- Development of robust, validated informatics tools to enable accurate carbohydrate and glycoconjugate structural prediction, computational modeling and data mining
- Establishment of a long-term-funded, stable, integrated, centralized database, including mammalian, plant, and microbial carbohydrates and glycoconjugates. Establishement of fully-crossed-referenced between the carbohydrate structural databases with databases providing complementary biological and structural information (e.g. PDB, GenBank,….)
- Recognition of the need to integrate glycoscience into relevant disciplines in high school, undergraduate and graduate education as well as developing curricula and standardized testing for science competency with the aim of increasing public as well as professional awareness.
Redefining the short and long-term research goals as well as pint-pointing the position of glycoscience among other biosciences is highly needed.