Anticarbohydrate Antibodies – from Molecular Basis to Clinical Application

The book compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. The book reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

Anticarbohydrate Antibodies
Anticarbohydrate Antibodies – from Molecular Basis to Clinical Application

• Multidisciplinary Approaches to Study O-Antigen : Antibody Recognition in Support of the Development of Synthetic Carbohydrate-Based Enteric Vaccines ( F-X. Theillet, P. Chassagne, M. Delepierre, A. Phalipon, & L.A. Mulard)
• Synthetic Oligosaccharide Bacterial Antigens to Produce Monoclonal Antibodies for Diagnosis and Treatment of Disease Using Bacillus anthracis as a Case Study ( M. A. Oberli, T. Horlacher, D. B. Werz & P.H. Seeberger)
• The Role of Sialic Acid in the Formation of Protective Conformational Bacterial Polysaccharide Epitopes (H. J. Jennings)
• Antibody Recognition of Chlamydia LPS : Structural Insights of Inherited Immune Responses (R.J. Blackler, S. Müller-Loennies, L. Brade, P. Kosma, H. Brade, & S.V. Evans)
• Designing a Candida albicans Conjugate Vaccine by Reverse Engineering Protective Monoclonal Antibodies (R. Bundle, C.Costello, C.Nycholat, T.Lipinski & R. Rennie)
• The Neutralizing Anti-HIV Antibody 2G12 (R. Kunert)
• Immune Recognition of Parasite Glycans (R.M. Maizels & J.P. Hewitson)
• Human IgE Antibodies Against Cross-Reactive Carbohydrate Determinants (W. Hemmer)
• Structural Glycobiology of Antibody Recognition in Xenotransplantation and Cancer Immunotherapy (M. Agostino, W. Farrugia, M.S. Sandrin, A.M. Scott, E. Yuriev, & P.A. Ramsland)
• Carbohydrate Mimetic Peptide Vaccines (S. Saha, A. Pashov, B. Monzavi-Karbassi, A.M. Kieber-Emmons, A. Otaki, R. Murali & T. Kieber-Emmons)
• Antitumor Vaccines Based on Synthetic Mucin Glycopeptides (U. Westerlind & H. Kunz)
• Glycan Microarray Analysis of Tumor-Associated Antibodies (O. Blixt, I. Boos & U. Mandel)
• A Novel Mannose 6-phosphate Specific Antibody Fragment for Diagnosis of Mucolipidosis type II and III (S. Pohl, T. Braulke, & S. Müller-Loennies)
• Anti-glycolipid Antibodies in Guillain-Barré Syndrome and Related Neuropathies : Therapeutic Strategies for Disease Treatment (R. K. Yu, S. Usuki & T. Ariga)
• Computational Techniques Applied to Defining Carbohydrate Antigenicity (R.J. Woods & A. B. Yongye)
• The Interaction of Saccharides with Antibodies. A 3D View by Using NMR (F. Marcelo, F. Cañada, & J. Jiménez-Barbero)
• Determination of Antibody Affinity by Surface Plasmon Resonance (R. MacKenzie & S. Müller-Loennies)