16

août 2018
Author(s) :

L. Lembo-Fazio, J.-M. Billod, F. Di Lorenzo, I. Paciello, M. Pallach, S. Vaz-Francisco4, A. Holgado, R. Beyaert, M. Fresno, A. Shimoyama, R. Lanzetta, K. Fukase, D. Gully, E. Giraud, S. Martín-Santamaría, M.-L. Bernardini & A. Silipo
Sources :

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex; Front. Immunol., August 2018 | https://doi.org/10.3389/fimmu.2018.01888

Bradyrhizobium Lipid A

Lipopolysaccharides (LPS) are potent activator of the innate immune response through the binding to the myeloid differentiation protein /toll-like receptor complexes. Photosynthetic Bradyrhizobium strains, symbiont of Aeschynomene legumes, express distinctive LPSs bearing very long-chain fatty acids with a hopanoid moiety covalently linked to the lipid A region. The article describes reprts on the structures and the immunological properties of LPSs isolated from Bradyrhizobium strains on both murine and human immune systems.