Multivalent Scaffolds in Glycosciences

The issue n°42 of Chemical Society Reviews devoted to the theme of “Multivalent Scaffolds in Glycosciences” assembles 18 contributions that provide a timely description of the several families of molecular scaffolds that all contribute to help deciphering the complexity of multivalent interactions which are play in many protein-carbohydrate interactions. Beside contributing to our understanding of the glycocode through multivalency, numerous applications of multivalent glyco-architectures have emerged. They encompass therapeutic opportunities (antimicrobial strategies, vaccines, targeted drug delivery,…) to diagnostic applications and cell and tissue imaging.

Multivalent Scaffold in Glycosciences

• Multivalent scaffolds in glycoscience : an overview
• Multivalency in heterogeneous glycoenvironments : hetero-glycoclusters, -glycopolymers and -glycoassemblies
• Sweet carbon nanostructures : carbohydrate conjugates with carbon nanotubes and graphene and their applications
• Clustered carbohydrates in synthetic vaccines
• Glycoclusters on oligonucleotide and PNA scaffolds : synthesis and applications
• Carbosilane glycodendrimers
• Multivalent glyco(cyclo)peptides
• Bacterial toxin inhibitors based on multivalent scaffolds
• Multivalent glycocalixarenes for recognition of biological macromolecules : glycocalyx mimics capable of multitasking
• Multivalent glycoliposomes and micelles to study carbohydrate–protein and carbohydrate–carbohydrate interactions
• Multivalent glycoconjugate syntheses and applications using aromatic scaffolds
• Multivalent glycoconjugates as anti-pathogenic agents
• Glyconanoparticles as multifunctional and multimodal carbohydrate systems
• Cyclodextrin-based multivalent glycodisplays : covalent and supramolecular conjugates to assess carbohydrate–protein interactions
• Enzymatic glycosylation of multivalent scaffolds
• Binding sugars : from natural lectins to synthetic receptors and engineered neolectins
• Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors
• How do multivalent glycodendrimers benefit from sulfur chemistry ?