The avidity of Norovirus Towards α-Fucose Riched Oligosaccharides
Norovirus infection routes in humans direct the pathogen to gastrointestinal epithelia via recognition of blood-group active mucin-type O-glycans. However, the glycan epitopes characteristic of Human Blood Groups Antigens are also present on oligosaccharides abundant in human milk oligosaccharides. These oligosaccharides play an essential role in protecting newborns. The comparison of the binding of norovirus to human gastric mucins and Human Milk Oligosaccharides indicates a profound avidity of the virus towards α-fucose containing oligosaccharides.
Mimicry of these epitopes with α-fucose multivalently displayed on other carbohydrate scaffolds successfully scavenged this prevalent virus.