22

juillet 2017
Author(s) :

C. Lee, J. Guo, W. Zeng, S. Kim, J. She, C. Cang, D. Ren & Y.Jiang
Sources :

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature (2017) doi 10.1038/nature23269 PDB: 5VRE

The Lysosomal Potassium Channel Represents a Previously Undescribed Fold

The lysosomal potassium channel (TMEM175) is a lysosomal K+ channel is a transmembrane protein which maintains the membrane potential and pH stability in lysosomes. The resolution of the crystal structure of TMEM175 channel from Chamaesiphon minutus, reveals a previously undescribed architecture of the tetrameric cation channel whose ion selectivity mechanism appears to be distinct from that of the classical K+ channel family.